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KMID : 1002120050020010016
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Journal of Korean Sleep Research Society
2005 Volume.2 No. 1 p.16 ~ p.20
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Sleep and Endocrinology
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Lee Ho-Won
Park Sung-Pa
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Abstract
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A bidirectional interaction between sleep electroencephalogram and endocrine activity is well established in humans. The studies suggest that various hormones (peptides and steroids) participate in sleep regulation. Growth hormone (GH)-releasing hormone (GHRH) stimulates GH and slow wave sleep (SWS), and inhibits cortisol, whereas corticotropin-releasing hormone (CRH) exerts opposite effects. Changes in the GHRH:CRH ratio contribute to sleep-endocrine aberrations during normal aging. In addition, galanin and neuropeptide Y promote sleep, whereas, in the elderly, somatostatin impairs sleep. In human vasoactive intestinal polypeptide appears to play a role in modulating rapid eye movement (REM)-nonREM cycle. Cortisol stimulates SWS and GH, probably by feedback inhibition of CRH. Neuroactive steroids exert specific effects on the sleep EEG.
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KEYWORD
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Sleep, Hormones, Aging, HPS system, HPA system
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